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KMID : 0882420070730030480
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Korean Journal of Medicine
2007 Volume.73 No. 3 p.480 ~ p.490
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Prevalence and risk factors of gallstones in a general health screened population
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Chung Yun-Jin
Park Young-Dae
Jeon Seong-Woo
Cho Chang-Min
Tak Won-Young
Kweon Young-Oh
Kim Sung-Kook
Choi Yong-Hwan
Park Kwan-Sik
Lee Hyun-Jeong
Kim Jong-Sub
Lee Ho-Chul
Cho Han-Jin
Seo Eun-Hee
Chung Joon-Mo
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Abstract
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Background : Gallstone is the most common disease of the biliary system. Most cases of gallstone are asymptomatic and we incidentally found gallstones during a community health survey. Our study was designed to determine the prevalence and risk factors for gallstone in a population who underwent health screening.
Methods : We enrolled a total of 36,314 persons who visited the health promotion center in Kyungpook National
University Hospital in Korea from 1998 to 2004. They had their gallbladder or biliary system examined with using
ultrasonography. The body mass index and biochemical parameters from liver function tests, the lipid profiles and the
fasting blood sugar were all measured. All the subjects were divided into several groups and the particular prevalence
for gallstone disease for each group was calculated. Chi-square tests and logistic regression analysis assessed the risk
factors for gallstone disease.
Results : Among 36,314 persons, (19,345 males (53.3%) and 16,969 females (46.7%)), gallstone was found in 735
persons (2.0%). On univariate analysis, the risk factors for gallstone disease were age, body mass index, fasting blood
sugar, total cholesterol, LDL-cholesterol, triglyceride and serum aspartate aminotransferase. On multivariate logistic
regression analysis, the the risk factors were high body mass index, older age and high fasting blood sugar.
Conclusions : The risk factors seem to show a common pathogenesis for gallstone disease. Although the relation
between gallstone disease and metabolic syndrome has not been established, it appears to be associated with metabolic
syndrome, but further study on a general population is required.(Korean J Med 72:480-490, 2007)
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KEYWORD
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Gallstone, Prevalence, Risk factor, Metabolic syndrome
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